498 Answered Questions for the topic genetics

Genetics Evolution

06/01/19

Validity of the August Weismann mouse-detailing experiment refuting Lamarckism?
Weismann conducted the experiment — [described in Wikipedia](https://en.wikipedia.org/wiki/August_Weismann) — of removing the tails of 68 white mice, repeatedly over 5 generations, and reporting... more
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05/31/19

Why and how does complexity usually tend to increase through time?
The question of complexity is classic in the very first lectures of evolutionary biology where the teacher usually tries to tell the students that complexity does not necessarily increase and that... more
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05/30/19

What method would you use to genotype SNPs in low quality samples?
What method would you use to genotype SNPs in low quality samples? I ideally want to genotype hundreds of SNPs in hundreds of scat samples (very low amount of target DNA, potentially degraded and... more
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Genetics

05/30/19

Are all chromosomes equally susceptible to mutation?
The humans have been around for a few million years, other organisms longer yet. Changes that occur in the genome and propagate (may) eventually throw a new species ... or atleast branch off the... more
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05/30/19

What are some (bioinformatic) methods to characterize potentially novel gene transcripts?
I am working with a few novel transcripts of genes- before I confirm their existence experimentally, I would like to perform some bioinformatic analysis. I have already considered coding potential,... more
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05/30/19

How can I find the mRNA sequence for a specific prokaryotic gene?
What I want to find out is the start of the transcription for a specific gene, how long the UTR is before the actual coding sequence starts.I've looked at various databases like NCBI Gene, Refseq... more
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Genetics Genomes

05/29/19

Drosophila reference genome?
Does anyone know the details about which line they are using to sequence as the *Drosophila melanogaster* reference genome?
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05/29/19

Hardy Weinberg principle?
The principle is that sum total of all allelic frequencies is 1.Individual frequencies for example can be named p,q.In a diploid cell , p and q represent the frequency of allele A and a... more
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Genetics Chromosome Genomics

05/29/19

Are recessive, deleterious alleles less common on the X chromosome than the autosomes in humans?
As there is a potential for them to be more readily purged in hemizygous males (and in cell lineages in females with the deleterious-allele-bearing chromosome activated), I would expect the... more
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05/29/19

How did genome duplication in jawed vertebrates allow gene specialization?
I am currently reading from Chapter 15 in Principles of Life, 2nd Edition:>Many gene duplications affect only one or a few genes at a time, but in some cases entire genomes may be duplicated.... more
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05/28/19

What are the advantages and disadvantages of using beta-galactosidase compared to luciferase as a reporter gene?
In the University labs, we have used Beta-galactosidase as a reporter gene to quantify the expression initiated by the stress-response promoter in yeast. This was done by exposing one of the two... more
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05/27/19

How do you merge SNP data with a reference genome?
# My DataI have a 23andMe file listing SNPs in the form:`rsid chromosome position genotypersXXXXX 1 PPPPPP CTrsXXXXX 1 PPPPPP ... more
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05/24/19

How is the exogenous DNA protected from degradation during bacterial transformation?
During transformation, a bacterium can take up DNA from its environment. A small fraction of bacterial species are known to be naturally competent, meaning that they can engage in this sort of... more
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05/24/19

How often does bacterial transformation happen?
I have been reading:>M. Dröge, A. Pühler, W. Selbitschka, "Horizontal gene transfer among bacteria in terrestrial and aquatic habitats as assessed by microcosm and field studies", Biol. Fertil.... more
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05/24/19

What's the aim of genetically modifying of foods/organisms?
On news, articles etc. experts talking about **Genetically Modified Foods and Organisms** often mentions about their disadvantages like, - their potential to harm human health - allergies may... more
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05/23/19

What is the definition of a mutation?
There are two alleles that determine the sensitivity of a person to Coumadin (a medicine for blood thinners used to treat a stroke etc). Sometimes you encounter the terminology that one has a... more
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Genetics

05/23/19

If a gene is located on the X chromosome, does that mean males are never heterozygous for these genes?
As said in the title I am a little confused on the idea of traits located on the sex chromosomes. The example we worked on in class was haemophilia, a recessive trait located on the X chromosome.... more
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05/23/19

Why are some genes dominant over others? What is the mechanism behind it?
If I have a brown eye gene which encodes the protein that is responsible for the brown color and have a blue eye gene as well, what is the reason that my eye color is brown? How does one gene... more
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05/23/19

How could a species be engineered to go extinct?
Non-biology background here. I read this very interesting article: https://www.wired.com/story/crispr-eradicate-invasive-species/ However I am having a hard time wrapping my head around... more
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05/22/19

How was the Huntington's disease gene's location found?
I read in the book "Why we get sick." by Nesse and Williams that:> Steady detective work and fabulous luck have enabled geneticists to> pinpoint the Huntington's gene on the short arm of... more
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05/22/19

What is the difference between "cistron" and "gene"?
I'm asking after reading the cognate wikipedia.en article on "cistron". I am still not sure about the difference between the two terms. To me it seems valid to picture a "cistron" as the genome... more
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05/22/19

Can sexual reproduction create new genetic information?
Is there a small chance that in sexual reproduction a new allele forms in the off-spring that was not present in either of the parents, or are the alleles in the offspring always from at least one... more
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05/22/19

Why has grey hair evolved?
A vast majority of humans get at least some grey hair as they age. As far as I know this applies to both genders and all races. Presumably this means that at least some grey haired humans have... more
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05/22/19

Books on population or evolutionary genetics?
I have recently been involved in collaborations that require me to model the population genetics of eukaryotic populations. I fear I may either be "re-inventing the wheel" or making conceptual... more
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05/22/19

What is the function of the RNA primer in DNA replication?
During DNA replication, RNA primase puts an RNA primer in the lagging strand. What is the function of this RNA primer? Why can't the enzymes put DNA fragments directly?
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