23 Answered Questions for the topic Molecular Genetics

07/31/19

#### Cell cycle selection?

Is it possible to select from colonies only cells which are at a certain stage in the cell cycle? E.g. if I was trying to analyse expression of a number of genes during different stages of the cell... more

07/08/19

#### Does the genome make sense without knowledge of the ovum?

Much of the literature for laypeople seems to consider (and to spreadthe idea) that an animal (or a plant, I guess) is characterised by itsgenome. I do not know whether the same goes for more... more

07/01/19

#### What exactly happens if during translation, an amino acid is not present?

Lets say that the cell wants to make a particular protein. Transcription of the appropriate gene is done and the mRNA is made. mRNA attaches to the ribosome and the translation is initiated in a... more

07/01/19

#### Are there known downsides to removing UV mutation hotspots to prevent some skin cancers (Genetic sunblock)?

Khavari et al. recently demonstrated that a significant fraction of one of the major forms of skin cancer (cutaneous squamous cell carcinomas) are associated with a mutated KNSTRN gene (a protein... more

07/01/19

#### Why is mRNA needed in the Protein translation?

The original question was to predict the basic requirements for information storage. Then the discussion moved to why is it necessary to include mRNA in the protein translation process. Why can't... more

06/17/19

#### How was gene therapy able to cure diseases through the transformation of actively dividing cells?

I thought that gene therapy, when performed on target cells that regenerate themselves constantly, can be effective for a limited time only. I.e., the effect gradually wears off after a while,... more

06/14/19

#### Is there a term for when a detrimental gene can be positively selected for because of linkage to a very fit gene?

Let's say that some piece of DNA would be subject to extreme negative selection if it were independently inherited, but it is very closely linked to an extraordinarily fit gene, and so the complex... more

06/14/19

#### What is the origin of "melting" in molecular genetics?

I'm reading some papers about prokaryotic transcription mechanisms, and I've come across a term I haven't heard before: *DNA melting* or *promoter melting*. After reading a bit, it's pretty clear... more

06/13/19

#### Constant or variable number of chiasmata during recombination?

During recombination, is the number of chiasmata consistent for each gamete and are the chiasmata regions consistent within a single organism?

06/10/19

#### What is the difference between the mitotic spindle and microtubules?

In mitosis, I understand that the centromeres line up on the spindle. I also know that the centrioles form microtubles between the centromeres during mitosis in the metaphase. But, are microtubles... more

06/07/19

#### How was gene therapy able to cure diseases through the transformation of actively dividing cells?

I thought that gene therapy, when performed on target cells that regenerate themselves constantly, can be effective for a limited time only. I.e., the effect gradually wears off after a while,... more

06/05/19

#### Out of the Cell: toward the ribosome

Which is the cellular organelle that has two parts: Big and Small?

06/04/19

#### What came first? The DNA or the DNA polymerases?

I know this sounds a lot like chicken and egg question and while the latter has an answer, I am intrigued about the former.A modified form of the question would be, in the course of abiogenesis,... more

05/30/19

#### Are there known downsides to removing UV mutation hotspots to prevent some skin cancers (Genetic sunblock)?

Khavari et al. recently demonstrated that a significant fraction of one of the major forms of skin cancer (cutaneous squamous cell carcinomas) are associated with a mutated KNSTRN gene (a protein... more

05/24/19

#### What's the aim of genetically modifying of foods/organisms?

On news, articles etc. experts talking about **Genetically Modified Foods and Organisms** often mentions about their disadvantages like, - their potential to harm human health - allergies may... more

05/22/19

#### What is the difference between "cistron" and "gene"?

I'm asking after reading the cognate wikipedia.en article on "cistron". I am still not sure about the difference between the two terms. To me it seems valid to picture a "cistron" as the genome... more

05/18/19

#### Can human mRNA be translated in vitro by prokaryotes?

As the genetic code is universal, can mRNA from a human cell be correctly translated by a prokaryote in a in vitro translation system?

04/01/19

#### Are mutations a source of genetic variation?

Here is a question from the book *SAT II Success Biology E/M* (where the SAT is the exam taken by the American high school students): > Which of the following statements is true about... more

04/01/19

#### Redundancy of the genetic code?

One particular codon codes only for one amino acid, but an amino acid can be coded for by several different codons. Now according to the genetic code, the codon UUU codes for the amino acid... more

03/27/19

#### What is the functional and structural distinction between core (H2A, H2B, H3,H4) and linker(H1/H5) histones?

Many explanations of histone biochemistry isn't quite elucidating for the undergraduate student. How does histone structure (dimers, octomers) relate to their specific functions as core or linker... more

03/14/19

#### Redundancy of the genetic code?

One particular codon codes only for one amino acid, but an amino acid can be coded for by several different codons. Now according to the genetic code, the codon UUU codes for the amino acid... more

01/29/16

#### Guanine and cytosine are what?

double ring structure

01/29/16

#### Adennie, Thymine, and Uracil are classified as what?

single ring structure

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