Hello again friends,
Yes, you two other experts, I will agree with you that E is the best response to the query that is presented here.
First off, one can easily abandon option C as a good one, because its second fill-in-the-blank word is the singular "extreme," and the filler-in has to be plural, so as to meet the grammatical rule of how to fill in "all of its..."
Next, one would probably not want to choose A or D, either, since problems do not typically hold "positions" or "thoughts;" selecting one of these would mean that things are being anthropomorphized, given human tendencies, and although lots of problems may be provoked by us humans, those problems are not human themselves.
Now, a decision has to be made between B and E, but once again, it is probably better to address a problem rather than to embrace it; staying away from as many human references as possible leads to more objective and clear writing.