Identify blood and lymphatic disorders question

Question

For each of the following characteristics, identify the blood or lymphatic disorder(s) in which they occur:

NOTE: For most, I wrote down what I think occurs in these scenarios, I'm just wondering if they are correct and/or if I missed any other important disorders.

1. Increased hematocrit without an actual increase in the number of red blood cells: This one I don't know....
2. Involves both excessive bleeding and clotting: This is caused by disseminated intravascular coagulation.
3. Characterized by primitive blast cells: Leukemia can cause this, acute leukemia especially
4. Sex-linked bleeding disorder: Hemophilia A
5. Megaloblastic RBCs: Megaloblastic anemia
6. Increased production of erythrocytes with a high hematocrit, high EPO levels and low O2 saturation: Secondary Polycythemia
7. A neoplastic disorder involving the red blood cells: Polycythemia vera, myeloproliferative neoplasms
8. Generalized pruritus (itchy skin) is common: Hodgkin’s lymphoma, sometimes present in Non-Hodgkin lymphoma, though not to the same severe extent as Hodgkin’s, and can be present in cutaneous T-cell lymphoma

Answer 1

Hey Amanda!

I'll give the ones you're not sure about a try

1) Blood can become concentrated during states of dehydration or burns when the absolute # of RBCs remains the same but the hematocrit which the proportion, by volume, of the blood that consists of red blood cells increases. In a sense, this may not be a pathology but strictly hemaconcentration.

5) Megaloblastic anemia are a group of anemias generally considered to be macrocytic (MCV >100fL) where DNA synthesis is impaired. Examples of megaloblastic anemia include folate deficiency, B12 deficiency.

8) Pruritus can also arise in polycythemia vera after a hot bath or shower.

Otherwise you are on the right path with the rest of the questions!