What is the biological mechanism underlying caffeine intolerance? (CYP1A2 or other?)?

Question

As far as I can tell, caffeine metabolism occurs primarily via the CYP1A2 enzyme. I am curious as to whether mutations in the CYP1A2 gene are associated with caffeine intolerance. Some site that is not necessarily reputable suggested that caffeine intolerance is due to absence of the enzyme to metabolize caffeine. I am having difficulty finding evidence either supporting or contradicting this claim.Does anyone know if there is evidence that suggests mutations in CYP1A2 (and therefore inability to properly metabolize caffeine) are associated with caffeine intolerance, or if there is another proposed mechanism for caffeine intolerance?

Answer 1

Asked and answered.

Answer 2

I can't give you specific references regarding your question, but having worked in the area of pharmacology for more than 25 years, I am familiar with the fact that there are several gene variants of CYP1A2 that affect its activity. There are "high" and "low" metabolizers. There are also other factors that are known to affect sensitivity fo caffeine, such as age, gender, interaction with other drugs, etc.