Which of the following could happen if human DNA were methylated?

Question

1. A. DNA binding proteins, which could not bind to DNA when it was not methylated, are now able to bind
2. B. Histone proteins, which package DNA, are no longer able to bind to DNA once it becomes methylated.
3. C. Many transcription factors will assemble on the DNA once it becomes methylate
4. D. The DNA could be cut by the Cas9 enzyme

Answer 1

The correct answer to this question is A. Once DNA is methylated, DNA methyl binding proteins can bind to DNA and recruit histone complexes. Histone complexes play a key role in modulating gene expression.