
Larry C. answered 03/16/19
Computer Science and Mathematics professional
Not from NYC to San Francisco because the route was not operated by any one rail line. However, up until a few years ago when a hurricane demolished a critical bridge that has yet to be replaced, there was an Amtrak train that ran all the way from Jacksonville, Florida to Los Angeles. Currently, it only runs between LA and New Orleans. (I lived in Jacksonville at the time and had intended taking the trip some day...unfortunately, I waited too long.)