good explanation needed i need help

Question

A person claims that aspirin is not “natural” and refuses to use it to relieve their pain. Which of the statements best refutes (argues against) this person’s claim? 

Aspirin has been used to relieve pain since the 5th century BC.

Aspirin can be considered natural because it is made from Salicylic acid which comes from a tree.

Aspirin is made in a laboratory so it is pure.

Salicylic acid causes stomach pain.

Answer 1

Hello, the second option is the "best" evidence to refute this claim.

Aspirin can be considered natural because it is made from Salicylic acid which comes from a tree.

Option 1, just because something has been using for hundreds of years doesn't mean its naturally occurring.

Option 3, cubic zirconium is "pure" diamond, but it's made in a lab and is therefore not naturally occuring.

Option 4, this is just a wrong answer.