Asked • 07/22/19

How can E. coli affect C. elegans expression?

Plasmids can be transferred to *E. coli*. These transformed *E. coli* can be fed to *C. elegans* to silence its gene expression by RNAi. How can *E.coli* release RNAi to *C. elegans*? Even if we assume *E. coli* could enter cells of *C. elegans* for being intracellular Bacteria, it is hard to imagine that RNAi will exit *E.coli* directly and enter *C.elegan*'s cells? Normally, no cells or bacteria will release RNA or genomic material outside of their cells?

1 Expert Answer

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Kenneth S. answered • 07/22/19

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