
Lawrence F. answered 06/01/19
PhD candidate, teacher, and researcher
The numbness and tingling you feel when your foot "falls asleep" is due to interference with the nerves that provide sensory innervation. When you sit in a weird position, you can compress these nerves and they stop sending the signals that our brains interpret as sensation. In some conditions, nerves responsible for sensation are chronically compressed, which can lead to neurological symptoms like numbness and pain. One such condition is sciatica, in which chronic compression of the sciatic nerve leads to recurrent numbness and pain in the lower limb.
After changing positions, restoration of nervous function and normal blood flow can result in a "pins and needles" sensation. You do not typically lose blood flow altogether since the circulatory system has multiple routes by which it can supply blood to a given tissue. So, if one artery is completely compressed, there's usually another one that can ensure a constant blood supply. If there is complete loss of circulation, this would eventually lead to tissue death due to oxygen deprivation.