Define the meaning of the term ‘peptic ulcer disease’.

Question

Define the meaning of the term ‘peptic ulcer disease’. Discuss some of the risk factors that make people susceptible (including factors that protect the mucosa of the stomach/duodenum and those that cause damage to it).

I need help with this question

Answer 1

Peptic Ulcer Disease (PUD) is like others have stated a disease process in which there are ulcers located within the stomach or the first part of the duodenum. The pathophysiology behind PUD can be complex and depends on the actual reason for the disease. Common reasons people develop PUD are overuse of medications like Aleve and Advil, H. Pylori infection, and sometimes tumors such as gastrinomas.

The main pathology occurs due to a disruption of the mucosal barrier of the stomach which allows for the acidity of the stomach to injure the walls. The reason for disruption in each case is different:

1. For medications such as NSAIDs the reason is that NSAIDS block prostaglandin production which allows for increased mucosal secretion, so you block mucosal production
2. For H. Pylori- the bacteria itself has an enzyme called urease which breaks down the acid and allows it to thrive in the stomach. Additionally, the bacteria have a mucinase that breaks down the mucosal barrier leading to ulcer formation.
3. For tumors like gastrinoma- this is due to the tumor producing increased unchecked gastrin which is the hormone responsible for HCl secretion into the stomach. Since this is unchecked and unregulated the acidic burden overwhelms the mucous barrier leading to ulcers.

Hope this helps with the pathophys more!

Answer 2

Ulcers. Damage to the stomach, small intestine, or esophageal lining is known as peptic ulcer disease.

Peptic ulcer illness is a form of peptic ulcer that affects the stomach. A duodenal (duodenal) ulcer is a peptic ulcer that occurs in the first segment of the small intestine. An esophageal ulcer in the lower section of the esophagus is a form of esophageal ulcer.

Peptic ulcers are open sores on the stomach's inner lining and the upper part of the small intestine. The most common symptom of a peptic ulcer is stomach pain. Peptic ulcers can manifest themselves in a number of ways:

1. Peptic ulcers are slow-growing lesions on the inside of the stomach.
2. Ulcers in the upper section of the small intestine are known as duodenal (duodenal) ulcers.

Factors that are at risk

1. Smoke. In patients infected with H. influenzae type b, smoking may increase the incidence of peptic ulcers. pylori.
2. Consume alcoholic beverages. Alcohol can irritate and dissolve your stomach's mucous lining, as well as increase the amount of stomach acid produced.
3. Have stress that is not being addressed.
4. Consume spicy meals.

Answer 3

So Sami F.,

Read up on the condition on Google. A Risk Factor is anything that the patient has or does that makes it more likely that they'll get the condition. Particular foods, drinks, medicines (usually, oral), other diseases, air they breathe, stress level in their life, and so on. SInce mucus secretion protects the stomach lining against attack, their immune system is of particlar interest. Certain drugs certainly do influence mucus secretion, and certain beverage habits also. Not to mention H. pylori!

But if you think peptic ulcer is bad, see buruli ulcer. Lots of stuff in the world we can't yet treat well. Perhaps some day you'll be on a research team that makes progress on one of those.

-- Cheers, --Mr. d.