The answer to the first question is the product of 4 binomial coefficients (which I will not calculate for you);
12C4 * 16C3 * 11C2 * 18C6 but I have little doubt that the answer can be as big as you quote.
For the 2nd question you need to remember that
P(A or B) = P(A) + P(B) - P(A and B).
I am not sure how to answer you own question which is not clear. If you can re=phrase and clarify in a comment, I will try to respond.