Arwa A.

asked • 03/23/21

About human HOXD13 (genetics), protein sequence alignment, protein sequencing. Orthologues and paralogues

  1. Construct a multiple protein sequence alignment using human HOXD13 and 9 other orthologues of human HOXD13. In the figure legend, describe what is being shown, and specify the size (start and stop number of amino acid) and location of conserved domain(s) in HOXD13 [5 marks]
  2. In FASTA format, download the following Human protein sequences for HOXA13, HOXB13, HOXC13, HOXD13; using the ALIGN function in UniProt, generate a multiple protein sequence alignment. In the figure legend, describe what is being shown (orthologues or paralogues?), and comment on DNA conservation, including a comparison with the alignment presented in question 1 [5 marks]

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