LMNA Gene Functional Annotation

Question

My assignment asks:

"Functional annotation: Identify functional domains in LMNA and its orthologs in different species or paralogs in this species. How do the domains vary between homologs? Has the function of the gene varied across species / with time? How does it vary between paralogs?"

I need to do that and carry out some computational analysis myself, but I am not sure where to start.

Answer 1

I can help you with that, specifically with the use of the UCSC genome browser, ensembl.org, or NCBI BLAST to do this kind of comparison, but it is a bit too complicated, with too many steps, to explain here. If you want to meet in a session, I can guide you through it.