What does not play a role in increasing oxygen unloading at tissue with someone who is iron deficiencent

Question

1. The affinity of 2-3 DPG for hemoglobin
2. An increase in deoxyhemoglobin
3. An increase in 2-3DPG
4. respiratory acidosis

Answer 1

Someone who is iron deficient will also be deficient in an essential part of the hemoglobin protein. This protein uses iron molecules to bind to oxygen, & without the iron t the oxygen cannot bind.

2,3 DPG (Also called 2,3 BPG) has an affinity for hemoglobin & is what we call a negative heterotrophic regulator. Negative means that when it binds, it decreases the enzyme's affinity for the substrate. Heterotrophic means that it is a different molecule than the substrate (ie. it is not oxygen). So when 2,3 DPG binds to hemoglobin, the protein will let go of oxygen. Therefore A & C are not correct answers.

Respiratory acidosis is when your blood stream becomes acidic due to not getting rid of CO2 fast enough. CO2 in the blood will be converted into HCO3- & H+, which increases the acidity. The Bohr effect describes hemoglobin has a decreased affinity for oxygen & will let go of the molecule. This part makes sense too, because it will result in more oxygen being delivered to muscle tissue that is working harder & outputting more CO2. Therefore D is not the right answer.

This leaves us with C. Logically, this makes sense too, because an increase in deoxyhemoglobin cannot result in increased oxygen delivery... because the protein isn't even carrying it to begin with.

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Michael G.