What is the normal function of the lamina densa?

Question

Laminins are high molecular weight (400 kD) glycoproteins of the extracellular matrix, present in nearly every tissue of an organism. They consist of three chains- α, β, and γ. Laminin defects are associated with muscular dystrophy, junctional epidermolysis bullosa, and kidney nephrosis. Laminin networks associate with collagen IV via entactin, fibronectin, and perlecan. They bind to integrins on cell membranes. The laminin trimer is named for its constituent proteins- laminin 332 is made up of proteins encoded by LAMA3, LAMB3 and LAMC2.The lamina densa lies at the boundary between the epidermis and the dermis and is composed of type IV and VII collagen and glycoproteins. What is the normal function of the lamina densa?

Answer 1

It filters molecules between the layers above and the layers below