
William W. answered 01/06/20
Retired Biology Professor: Tutor and Graduate Admission Consultant
It is not possible to answer most of these questions without making an assumption. The problem is that we have no way of knowing whether the spotted dogs were homozygous dominant or heterozygous. Even with a simplifying assumption, questions 1, 3 and 5 have multiple possible answers.
Let's assume that because 12 puppies were born from the cross (which is a large litter), both parents were not heterozygous. We might assume this because a heterozygote x heterozygote cross would produce, on average, 25% homozygous recessive embryos, which, because this is a lethal condition, would mean that there were 16 original embryos, a very large number. If this assumption is correct, then one parent could have been homozygous dominant and the other heterozygous, or both may have been homozygous dominant. From the information provided, there is no way to tell which of these is true. This means that there are multiple possible answers for some of the questions.
Because of the above, we have no way to answer question 1. A homozygous dominant spotted dog produces one type of gamete (spotted only), while a heterozygous spotted dog produces two types of gametes (50% spotted, 50% black). We don't know what genotype of spotted dog is being referred to in the question.
We also have no way of answering question 3. To see why, do two Punnet squares: one in which both parents are homozygous dominant, and one in which one parent is homozygous dominant and one is heterozygous. The crosses produce a different number of possible genotypes for the offspring.
Finally, we have no way of answering question 5. All could be homozygous, or half could be homozygous, depending upon the genotypes of the parents (see the results of the Punnet squares in the previous paragraph). If our initial assumption was wrong, it is also possible that 1/3 of the surviving puppies could be homozygous (do a Punnet square for a heterozygote x heterozygote cross and remove the homozygous recessive offspring that died as embryos).
I suspect that the question is misphrased, either in its original form or in the form transcribed here.

William W.
You should be able to determine this on your own. If the black phenotype only occurs in the homozygous recessive state, and if being homozygous for the black allele is lethal, then all surviving offspring are ________________.01/07/20
Done Z.
so what about 2 and 4 ?01/07/20