Are there any DNA base sequences that are fully conserved between the genomes of all humans?

Question

That is, they don't differ throughout the entire population. I understand of course that we can't DNA sequence every human, so by "fully" I mean there's an incredibly small probability of there being a mutation retained in a living individual.Also by the genome I'm referring to the consensus of all the cells composing in the individual.I guess my question is really, where are the crucially important sections of DNA that are simply unmodifiable without being incompatible with life?

Answer 1

That's a great question. Typically, sequences that are highly conserved relate to genes that have a highly important function, such as cell death proteins for example. These "functional" genes are usually so highly conserved that we can use them as evolutionary markers as they remain the same within a species, and sometimes even between different species. There are of course mutations that occur which cause these proteins to be defunct or act differently, but their conservation is incredibly important, if not in genetic sequences then in protein structure and function. I hope this answer helps!