Codo M. answered 10/20/23
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The primary (first) method of signal amplification used by all three receptors in this diagram is as follows: "Receptors activate AC, which creates second messengers." This means that the receptors stimulate adenylyl cyclase (AC), leading to the production of second messengers. Second messengers are crucial intracellular molecules that transmit and amplify the cellular response to external signals, typically regulating various cellular functions.