short note on CF3 containing biologicaly active molecules and factors influence on them

Answer 1

CF3-containing molecules have gained significant attention in drug discovery due to their unique physicochemical and pharmacological properties. The presence of a CF3 group can enhance the potency, metabolic stability, and lipophilicity of a compound, making it an attractive target for drug development. However, the introduction of a CF3 group can also impact the binding affinity and selectivity of a molecule, and its effects may depend on factors such as stereochemistry and electronic properties. Thus, understanding the influence of CF3 substitution on biological activity is an important consideration in drug design and optimization.