What type of cell signaling does Cholera deal in?

Question

I can not figure it out at all no matter what I search. Cholera toxins go through G-proteins in the signal transduction pathway, but what specific type of cell singling pathway does this virus go to? Is it direct pathway?

Answer 1

The catalytic portion of cholera toxin has an exclusive function. It seeks out the G proteins used for cellular signaling and attaches an ADP molecule to them. This converts the G-protein into a permanently active state. Therefore, it sends a signal that persists indefinitely.

Answer 2

Fire,

This is a great question! Cholera is a gastrointestinal disease caused by the bacterium Vibrio cholerae. As you have correctly pointed out, the cholera toxin produced by this bacteria creates pathology by stimulating adenylate cyclase via a g protein-coupled receptor. The result of this G protein-coupled receptor signaling in the intestines results in excessive water and chloride ion release into the intestinal lumen. The excess water and chloride are cleared from the body as rice-colored diarrhea, rapidly dehydrating the host. 

As for the bacteria itself, I am not sure about any other relevant signaling pathway that would cause disease. The toxin produced by the bacteria is the major culprit.