Describe THREE (3) ways in which antibodies can be used and modified to induce tumour cell death.

Answer 1

Hey Keanu,

There are multiple mechanisms by which antibodies induce tumor cell death.

1. Direct method: Antibodies directly stimulate receptors on the cell thatresult in activation of apoptosis pathways and lead to cell death
2. Complement Mediated: IgG binds to the complement factor C1q and leads to the formation of the membrane attach complex and cell lysis and death of the tumor cell
3. immune Cell Mediated: Antibodies lead to tagging of tumor cells in a process called opsonization, which leads to recruitment of immune cells, such as NK cells, macrophages, and neutrophils, which then leads to cell death

Here's an article below with more information. Figure 1 is particularly helpful.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282585/