Hello, thank you for taking the time to post your question!
The main difference is how much of the level of precision has changed over time. A common metaphor used to understand is that earlier genetic engineering was like trying to edit a book by cutting and pasting entire paragraphs, but modern techniques are more like using a find-and-replace function in a word processor. So over time it has become a far more powerful, affordable, and targeted tool.
Hopefully that gets you moving in the right direction! Feel free to reach out with a message if you have any questions beyond that! :)
