X-linked recessive disorders

Question

"Unlike X-linked recessive disorders, the frequency of X-linked dominant disorder is similar in males and females." 

However, these two syndromes (Rett syndrome and Incontinentia Pigmenti) are found almost exclusively in females. Why do you think that is? Think carefully about this.

Answer 1

Hi Rashid B.,

So what have you read about, say, Rett Syndrome? If you check out an (easily Googlable!!) website such as ht tps :/ / www. rettsyndrome. org / about-rett- syndrome /boys-with- rett / , you will be able to find that information specifically. It is NOT the case that (in males, since they have only a single X chromosome, if that is mutated therefore they have severe symptoms, and die very young (which they do, by the way) so that they do not appear in the clinical population!) There is another, quite different reason, which you will discover there.

-- Cheers, -- Mr. d. -- P.S. Copy and take all spaces out of the link, before you click it. That format is necessary to bypass Wyzant filters which do not allow links, sometimes, in Answers.