Suppose a gene has the DNA nucleotide sequence given below:

Question

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 

C T G G C A T G C T T C G G A A A

Explain each one of the following mutations below and how it would affect the protein. Then discuss which one would probably produce the greatest change in the activity of the protein for which this gene codes and justify your answer.

a) substitution of A for G in position 3

b) deletion of the C at position 5

c) deletion of the A at position 15

d) addition of G between position 14 and 15

Answer 1

1) C T A G C A T G C T T C G G A A A

2)C T G G A T G C T T C G G A A A

3) C T G G C A T G C T T C G G A A

4) C T G G C A T G C T T C G G G A A A