Which method will be quickest to identify the candidate genes?

Question

Humans have many genes. Some of the genes have an association with infectious diseases. And there are different methods to identify these genes. Suppose you want to identify the candidate genes associated with a disease caused by a particular bacterium. Which method will be quickest to identify the candidate genes?                                                                                                                            

Answer 1

You could do a variety of different techniques to identify candidate genes. The most straightforward would be RNA seq, where you can identify and quantify which genes are being expressed in differing conditions. After the human cell culture is infected with the bacterium, Genes that show a large increase or decrease in mRNA compared to healthy cells would be good candidate genes in this scenario.