
Kiera G. answered 09/14/20
Biology Tutor with B.S. in Biological Sciences
Imagine an enzyme as a pencil sharpener, and the substrate as a pencil. The shape of the sharpener in both the size of the hole and angle of the blade works perfectly to sharpen the pencil. If you changed the shape of the hole of the pencil sharpener, or the angle of the blades within it, it will no longer be able to sharpen the pencil. Either the pencil will not fit into the sharpener (the substrate does not bind to the enzyme) or the pencil fits but is not sharpened (substrate binds, but the enzyme is unable to catalyze the reaction).