If the (enzyme linked receptors) are signaling to cause cell migration, what could this receptor signal to in the cytoplasm?

Answer 1

integrin based signaling induces actin cytoskeletal remodeling and leading edge actin polymerization. The formation maturation and turnover of adhesive complexes act as temporary anchors for the cell to move past as they remain relatively stationary. rac and related family gtp-ase signaling accentuates this process, particularly actin cytoskeletal reorganization. mitogen activating protein signaling (both receptor tyrosine kinases and serine/threonine kinases) activate a variety os downstream signaling pathways. map like egf can stimulate matrix metallo-proteases the cell needs to maneuver through the cell matrix. additionally, migration stimulation in the absence of map's results in little motility, lending to the idea that a cell needs map signaling to activate the migration machinery (starve-stim). bottom line, pick your favorite signaling receptor and its associated downstream pathway and you'll almost certainly find at least one (if not 1000) papers implicating it in migration.