How do centrioles auto-locate to opposite sides of cell during mitosis?
I realize that centrioles are made of 9 triplets of microtubulin wound together with a hollow core, and that they are responsible for the configuration of the spindle during mitosis. The spindle fibers attach to the kinetochores of the sister chromatids and pull, ultimately separating them in preparation for cytokinesis. \n\nHow do the centrioles recognize where to go in the cell, such that they are oppositely positioned with one another? Is the mechanism similar to how neurons "find their way" during development to forge the correct connections that give us sight, etc, but on a subcellular scale?
Centrioles contain different types of microtubules that take part in positioning them within the cell. There are kinetochore microtubules that extend from centrosomes and attach to kinetochores on chromosomes and there are polar microtubules that extend from the two centrosomes and connect to one another. The polar microtubules then pushes the centrosomes to the opposite ends of the cell to prepare for replication!
