Asked • 05/27/19

How do the pharmacodynamics of the NSAIDs differ and are there "resistant" COX phenotypes?

I know that the non-steroidal anti-inflammatory drugs (e.g., aspirin, ibuprofen, naproxen) affect the enzymes cyclooxygenase (types I and II).Is there any difference in the degree to which these drugs manipulate/inhibit the enzymes (I assume their affinities for COX-1 and COX-2 are at least somewhat different)? Is there any evidence as to whether the the NSAIDs collect in certain areas of the body in a compartmental fashion?Are there differences in fat solubility, etc., between the different drugs?Finally, are there any known phenotypes of COX-1 and COX-2 enzymes that are present in the general population that affect the ability of these drugs to act?

1 Expert Answer


Huong N. answered • 07/07/20

5 (1)

Pharmacist, PharmD, MTM

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