Which variant of English should I use when my target audience is the world?

Question

I know that all variants of English ([American English](http://en.wikipedia.org/wiki/American_English), [British English](http://en.wikipedia.org/wiki/British_English), etc.) can be generally understood by everybody who knows any of the English variants. However, there are some regionalisms that can lead to ambiguity.
What are the things I must be aware of when the target audience (of my writing: book, blog, etc.) is the world?

Answer 1

I use American English, as I am an American and typically publishing in American journals. I would ask your publisher these questions. I do read blogs etc. written in British English, and I know these articles are written by British language speakers. In my opinion, the variation of English you use is less significant than the inclusion of quality content.