Hello Paula,
Use these rules of exponent to solve this problem.
1. am/an = am-n
2. a-1 = 1/a
3. am * an = am+n
4x-2y3/x5y-6 (original problem)
4 * (y3y6/x5x2) (x-2 = 1/x2 and 1/y-6 = y6)
4 * (y3+6/x5+2)
4y9/x7 ---------------->answer
Hope this helps.