Annani K. answered 07/13/23
MA in Psychology and PhD Candidate with an emphasis on consciousness.
Studies of this nature have been performed using various substances. They are always mixed methods - using quantitative analysis for the measurement and distribution of the substance and qualitative anaylysis (such as self-reporting, interviews, and questionnaires) for the subjective experience. For a great example of a mixed methods study on Psilocybin and Consciousness, see Kometer et al., (2015).
Kometer, M., Pokorny, T., Seifritz, E., & Volleinweider, F. X. (2015). Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations. Psychopharmacology, 232(19), 3663-3676. https://doi.org/10.1007/s00213-015-4026-7