Theresa L.

asked • 04/06/14

question help please

Blockage of _____ would be expected to decrease the levels of transmitters within the vesicles. A) presynaptic transporters B) axonal autoreceptors C) vesicular transporters D) postsynaptic autoreceptors E) degradation enzymes

Arianna H.

The answer is C: Vesicular Transporters. Just like it's name implies, this membrane protein helps to move (transmit) other molecules within the vesicles. If you block them, the levels of transmitters would decrease because the Vesicular Transporters wouldn't be there to transport them along.
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11/09/19

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Sandra H. answered • 12/02/14

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Its C) vesicular transporters- they transport NT into presynaptic vesicles, and when you block them, NT could not be transported into vesicles- so levels would go down....(by leakage, and release into synapse)
 
If you block presynaptic transporters, (which re-uptake NT that are released), the levels in vesicles COULD go down because there would be less NT in cytoplasm to transport into vesicles......  
Blocking axonal auto receptors (which prevent NT release from neurons) may actually RAISE NT levels in the vesicles.
I do not think post-synaptic auto receptors exist? 
Blocking degradation enzymes may RAISE NT levels in vesicles- so also not a good choice.
 
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