J.R. S. answered 10/11/20
Ph.D. in Biochemistry with an emphasis in Neurochemistry/Neuropharm
∆U = q + w
q = heat = -227 J (negative because the system is losing heat, i.e. exothermic)
w = -422 J (negative because the system is doing work on the surroundings)
∆U = -227 J + -422 J = -649 J