
Stone S. answered 07/29/19
Experienced College Level Tutor in Sciences and MCAT
The cytosol is a net negative charge and the extracellular fluid is a net positive charge.
The ion transporters (sodium/potassium pumps) ensure a net negative charge by constantly pumping 3 positively charged ions out of the cell for every 2 positively charged ions pumped into the cell. The negative charge inside the cell is also maintained by negatively charged particles such as Cl-