Can in the case of multiple sclerosis (MS), a too high osmotic pressure in the nerve, lead to a high intracellular concentration of potassium?

Question

Can in the case of multiple sclerosis (MS),a too high osmotic pressure in the nerve, lead to a high intracellular concentration of potassium,and also lead to 'pumping up' of nerve cells,which then due to the strongly increased internal pressure, the insulating myelin sheath can be pressed broken,resulting in a lesion, or a strong reduced transmission of stimuli ?If that were to happen, one can expect in cerebrospinal fluid,cytokines, which are normally also a component of the nerve cell contents, and that it wrongly can be interpreted,as inflammatory reaction to a potential autoimmune disease.Is there research of this ?

Answer 1

Interestingly, there are research studies on this, but i see a few have been retracted.

Cytokines in MS are thought to arise from T cells in the PNS, also resulting in CNS involvement. Have you considered how cytokines more broadly are involved in the affected myelin component of MS, particularly the resulting electrochemical gradient shift of intracellular Na and K?

A new thinking regarding an intracellular K overload is a focus of neuromorphic modeling that attempts to manipulate the Na/K pump channels. You might consider a novel generative approach to running the pump in these K conditions. The aim here is to artificially elicit depolarizing APs in the PNS of MS patients. Admittedly, this is experimentally translational, but would have a dramatic clinical outcome!