Daniel H. answered 10/08/19
Creative Videography Specialist — Editing, Writing, Drama, and more!
Some suggestions you may be able to use: if your target player is QuickTime, be sure to save your files as "self-contained," otherwise you'll end up with unusually small files with references to files on your local disk. You do not need to create a hint track ("Prepare for Internet Streaming") if you plan on using MPEG Streamclip.
I'd keep your native timeline resolution, the codec at H.264, and your current frame rate the same. Technically this depends if you are working with live video or presentation-style (think Powerpoint or Camtasia). Be sure to Key Frame every 10 seconds, this makes it easier for player scanning.
If you are doing computer presentation style (see above), try to keep your data rate around 250 kbit/sec, with audio AAC Low Complexity ("MPEG-4 audio"), around 64k bit/sec mono for speech.
If you're including live footage anywhere in the project, use Inspector in QuickTime Player Pro to determine the correct data rate (different cameras shoot at different rates), and stick to Linear PCM audio, 48k stereo.