Domains in cell membrane?

Question

How is movement of proteins and lipids between different domains of cell membrane prevented?Why is the noncytosolic layer not able to do lateral movements between domains but cytosolic layer is able to do so?

Answer 1

Lateral movement is not prevented at the noncytosolic layer. According to the prevailing theory of how the cellular membrane behaves, the fluid mosaic model, lipids and proteins behave as a fluid and move throughout the cell membrane. The theory applies to both layers of the cell membrane. As of now, there is no way to determine if the noncytosolic layer is stationary. However, science is always progressing so this may change in the future. You may be the one who develops this technique!