Meta-analysis of fruits in blocking Cytochrome family?
My professor says that some drugs cannot be used with grapefruit. I am trying to search a list of cytochromes and their effect to block members in the cytochrome family. Some in Cyt P450.**What is the main meta-analysis of fruits in blocking cytochrome family?**
Grapefruit inhibits the Cytochrome P450 (CYP) 3A4. Many medications undergo first pass metabolism through this system so it is important for absorption of the drug. CYP 3A4 is found in enterocytes of the small intestine and hepatocytes of the liver. It is important to note than genetics plays a role in the expression of CYP system. There are other fruits but grapefruit has been the most extensively studied.
