How does methamphetamine (meth) damage neurons?

Question

Meth is considered to be neurotoxic by forming reactive oxygen species and oxidizing the neurons. But unlike dopamine, which, by the way, [is neurotoxic due to ROS induced dopaminergic stress](https://www.ncbi.nlm.nih.gov/pubmed/23683503), meth **does not have any oxygen atom**, and thus cannot be the direct cause of ROS.So, how exactly does meth exert its neurotoxic effects?

Answer 1

There are several hypothesis. I will let you read about them yourself in this articles that explains it. Please comment here if you have more questions.

https://www.hindawi.com/journals/bn/2015/103969/