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Does a comma go before and

He was seen by a primary care physician who noticed he was anemic, and gave him red cell transfusions after a course of antibiotics did not improve.  
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2 Answers

Yes, that is correct. I would add one more suggestion towards the end of the sentence: "...after a course of antibiotics did not improve."  It is not a complete sentence, and is missing the object (the patient).  You would want to say something such as: "...after a course of antibiotics did not improve his condition."  I hope that makes sense.
Yes, it does.