A loading dose of acetylcysteine 8 grams, which is available as a 20% solution (200 mg acetylcysteine per ml) is prescribed by nasogastric tube for a client with acetaminophen toxicity. How many ml of diluent should be added to the medication to obtain a 1:4 concentration? ( enter the numerical value only. If rounding is required, round to the whole number.)
It would help to know what the ratio 1:4 is referring to. If you want 1 acetylcysteine to 4 dilutent, then you're already too dilute because that would be a 25% solution. If you want 1/4 the concentration of the 20% solution, then you can calculate dilutent (solvent) as follows. You want 8 grams of medication which can be found by multiplying 8 by 1000 to get mg, then multiply it by the reciprocal of the medicine's concentration to get the mL of solution. Then add three times the solution volume in dilutent to get the concentration to 1/4 of it's original strength. That would work out to 120 mL of dilutent.