partial derivative of f(x,y) wrt x is -2x/(1+(x-2)2+(y-2)2)
The second partial derivative of f(x,y) wrt x is [(1+(x-2)2+(y-2)2)(-2)+2x(2x)]/(1+(x-2)2+(y-2)2)2
The second derivative wrt y is the same as x with y and x switched (symmetry)
The mixed derivative d2f/dxdy is 4xy/(1+(x-2)2+(y-2)2)2