The integrand is the sum of two terms, each one of which is a power of x.
The anti derivative of xn is xn+1 /(n+1) So ∫ x dx = x2/2 and ∫ x3 = x4/4.
So with this information the desired definite integral is
2 x2 /2 |2 1 - 4 x4 /4 |2 1 = (22 - 12) - (24 - 14) = 3- 15 = -12