y-5 = a(x-4)^2
21-5 =a(8-4)^2 = 16a
a = 16/16 = 1
y-5 =(x-4)^2
y = (x-4)^2 +5 is in vertex form
for an upward opening parabola
or
x-h =a(y-k)^2
x-4 =a(y-5)^2
8-4 =a(21-5)^2
4 = a(16)^2
a = 4/16^2 = 1/64
x-4 = (1/64)(y-5)^2
x = (1/64)(y-5)^2 +4 in vertex form for a rightward opening horizontal parabola
8 = (1/64)(21-5)^2+4 = (1/64)(16^2) +4= 256/64 + 4 = 4+4 = 8
there are also an infinite number of slanted or "tilted" parabols with that same vertex through the given point
with xy, terms, as well as x^2, y^2, x or y terms, where the directrix is "tilted," not a vertical or horizontal line.
You probably want the first solution, which is the common standard parabola, upward opening.