Although it requires complex analysis to prove it, every polynomial of degree n with real coefficients has exactly n roots, some of which may be complex. Every real root corresponds to an x intercept.
For a0 >0, the y intercept is also greater than 0 and equal to a0.
Since an < 0, the graph goes to -∞ when |x| is large.
This means the graph must cross the x axis at least twice, i.e. the polynomial has at least 2 real roots.
This last comment depends on the fact that polynomials are continuous on the whole real line.