For differentiation with respect to x,
with 5/xa^2 meant to be 5/(ax)2,
one could write d[5/(a2x2)]/dx for
the derivative sought.
The derivative is then obtained as
(a2x2)(0) − (5)(2a2x)
------------------------------
(a2x2)2
which reduces to -10a2x ÷ a4x4 or -10/a2x3.