Here's how you do it.
1) If two lines are perpendicular to one another, then their slopes are negative reciprocals of one another. Hence all lines perpendicular to y = 3x - 5 will have a slope of -1/3. So the equation of a perpendicular line will be y = -(1/3)x + b
2) To find the particular perpendicular line that goes through the point (4,-3), plug the x and y values of the point (4,-3) into y = -(1/3)x + b then solve for b.