explain how bone is formed and remodled

Question

Receptor Activator of Nuclear Factor Kappa-B (RANK)

  - found on osteoclasts

RANK-Ligand

  - made by osteoblasts

  - binds to RANK and activates osteoclasts

Osteoprotegerin (OPG)

  - made by osteoblasts

  - competitively binds RANK binding sites

  - less RANK-L can bind

  - prevents activation of osteoclasts

Estrogen

  - limits RANK-L formation

  - decreases osteoclast activity

Answer 1

Please see below image that I found most helpful to understand bone formation vs resorption (Resource: Amboss)

How bone is formed and remodeled is by osteoblasts. I am not sure what you are asking because what you listed is a summary of how it's formed and remodeled. Please clarify your question so I can help more.

The human skeleton is in a continuous dynamic state of remodeling. Not only does this apply to the replacement of immature woven bone by lamellar bone, but also for adaptation of adult bones to their individual load.

Bone remodeling

Cells involved

1. Osteoclasts: degrade bone tissue by secreting collagenase and H+
2. Osteoblasts: Build bone tissue by secreting type I collagen

Activity assessed by an increase in bone ALP, osteocalcin, and type I procollagen propeptides

Duration: usually longer than the lifespan of the cells involved (continual replacement of involved cells)